Utilizing Human-Induced Pluripotent Stem Cells to Study Cardiac Electroporation Pulsed-Field Ablation.
Leonid MaizelsEyal HellerMichal LandesbergShany GlatsteinIrit HuberGil ArbelAmira GepsteinDoron AronsonShirley SharabiRoy BeinartAmit SegevElad MaorLior GepsteinPublished in: Circulation. Arrhythmia and electrophysiology (2024)
Cardiac electroporation may be studied using hiPSC-derived cardiac tissue, providing novel insights into PFA temporal and electrophysiological characteristics, facilitating electroporation protocol optimization, screening for potential PFA-sensitizers, and investigating the mechanistic nature of PFA antiarrhythmic properties.