Hypertrophic Adipocyte-Derived Exosomal miR-802-5p Contributes to Insulin Resistance in Cardiac Myocytes Through Targeting HSP60.

Zhongyuan WenJunfeng LiYalin FuYuyang ZhengMingke MaChanghua Wang

Published in: Obesity (Silver Spring, Md.) (2020)

Hypertrophic adipocyte-derived exosomal miR-802-5p caused cardiac insulin resistance through downregulating HSP60. These findings provide a novel mechanism by which epicardial adipose tissue impairs cardiac function.

Keyphrases

adipose tissue
insulin resistance
heat shock protein
high fat diet
left ventricular
heat shock
heat stress
metabolic syndrome
polycystic ovary syndrome
skeletal muscle
type diabetes
high fat diet induced
fatty acid
cancer therapy
oxidative stress
glycemic control