Dual Antiplatelet Therapy in Patients Aged 75 Years and Older with Coronary Artery Disease: A Meta-Analysis and Systematic Review.
Garly Rushler Saint CroixSpencer C LacyAmre GazzhalMichel IbrahimMedeona GjergjindreajJorge PerezMalik ShehadehKarthik VedantamChristian TorresNirat BeoharEsteban EscolarPublished in: Journal of interventional cardiology (2022)
This systematic review and meta-analysis suggests that DAPT with prasugrel or ticagrelor compared to clopidogrel is associated with a higher risk of bleeding events in elderly patients with ACS. There was no difference in the primary efficacy endpoints between the two treatment groups.
Keyphrases
- antiplatelet therapy
- percutaneous coronary intervention
- acute coronary syndrome
- coronary artery disease
- st segment elevation myocardial infarction
- systematic review
- st elevation myocardial infarction
- coronary artery bypass grafting
- end stage renal disease
- atrial fibrillation
- middle aged
- newly diagnosed
- community dwelling
- chronic kidney disease
- ejection fraction
- prognostic factors
- heart failure
- physical activity
- randomized controlled trial
- smoking cessation
- combination therapy
- patient reported outcomes