Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice.
Anna Martínez-MurianaDiego PastorRenzo MancusoAmaya RandoRosario OstaSalvador MartínezRubèn López-ValesXavier NavarroPublished in: Stem cell research & therapy (2020)
Overall, our findings suggest that targeting more than one affected area of the motor system at once with bone marrow cell therapy results in a valuable therapeutic intervention for ALS.
Keyphrases
- bone marrow
- cell therapy
- mesenchymal stem cells
- induced apoptosis
- amyotrophic lateral sclerosis
- stem cells
- randomized controlled trial
- cell cycle arrest
- high fat diet induced
- cancer therapy
- endoplasmic reticulum stress
- type diabetes
- oxidative stress
- signaling pathway
- drug delivery
- cell proliferation
- skeletal muscle