Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry.

Yuan HungCheng-Chih ChungYao-Chang ChenYu-Hsun KaoWei-Shiang LinShih-Ann ChenYi-Jen Chen

Published in: Biomedicines (2022)

Klotho inhibited pro-fibrotic activities and SOCE by inhibiting the PLC signaling and suppressing the TRP currents, which may provide a novel insight into atrial fibrosis and arrhythmogenesis.

Keyphrases

atrial fibrillation
signaling pathway
systemic sclerosis
endothelial cells
idiopathic pulmonary fibrosis
anti inflammatory
left atrial
catheter ablation
heart failure
extracellular matrix
pluripotent stem cells
left ventricular