Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region.

Young Chan KimCesar Lopez-CamachoJoanne E NettleshipNahid RahmanMichelle L HillLaura Silva-ReyesGeorgina Ortiz-MartinezGloria Figueroa-AguilarMaría Antonieta MarHéctor Vivanco-CidChristine S RollierNicole ZitzmannMartha Eva Viveros-SandovalRaymond J OwensArturo Reyes-Sandoval

Published in: Virology journal (2018)

Results obtained from this study indicate the potential of the Asian-lineage Zika Env-CD4 and Env proteins in ELISA assays to monitor humoral immune responses in upcoming clinical trials as well as a sero-diagnostic tool in ZIKV infection.

Keyphrases

zika virus
aedes aegypti
immune response
dengue virus
clinical trial
ejection fraction
newly diagnosed
prognostic factors
high throughput
randomized controlled trial
single cell
binding protein
toll like receptor
amino acid
human health
study protocol
risk assessment
inflammatory response
double blind