Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore.

Xin Qin Soh Doreen Su Yin Tan Eric Chun Yong Chan

Published in: Cardiovascular drugs and therapy (2022)

Our findings suggest that concomitant use of simvastatin with rivaroxaban may be associated with bleeding events in an Asian cohort. Further studies using physiologically based pharmacokinetic modelling are required to investigate the drug-drug interactions between these drugs.

Keyphrases

atrial fibrillation
venous thromboembolism
pulmonary embolism
drug induced
case control
emergency department