Eric Chun Yong Chan

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 34

Top Venues

Drug metabolism and disposition: the biological fate of chemicals

British journal of clinical pharmacology

Journal of chemical information and modeling

Cardiovascular drugs and therapy

National University of Singapore

This page only lists publications with an associated author ORCID identifier.

Affiliation History

National University of Singapore Jan 01 2019

Singapore

Professor :: Pharmacy

Publications

Wan Wei, Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan, Eric Chun Yong Chan
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations. Journal of chemical information and modeling 64 (6) (2024)
Wan Wei, Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan, Eric Chun Yong Chan
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations. Journal of chemical information and modeling (2024)
Wan Wei, Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan, Eric Chun Yong Chan
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations. Journal of chemical information and modeling 64 (6) (2024)
Lixuan Qian, Ziteng Wang, Mary F Paine, Eric Chun Yong Chan, Zhu Zhou
Application of physiologically-based pharmacokinetic modeling to inform dosing decisions for geriatric patients. CPT: pharmacometrics & systems pharmacology (2024)
Tat Ming Ng, Ziteng Wang, Eric Chun Yong Chan
Physiologically-based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID-19. British journal of clinical pharmacology (2024)
Ziteng Wang, Kylie Hoi Yan Luk, Eleanor Jing Yi Cheong, Sin Mun Tham, Revathi Periaswami, Poh Choo Toh, Ziting Wang, Qing Hui Wu, Woon Chau Tsang, Arshvin Kesavan, Alvin Seng Cheong Wong, Patrick Thomas Wong, Felicia Lim, Edmund Chiong, Eric Chun Yong Chan
Characterization and prediction of OATP1B activity in prostate cancer patients on abiraterone acetate using endogenous biomarker coproporphyrin I. Drug metabolism and disposition: the biological fate of chemicals (2024)
Wan Wei, Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan, Eric Chun Yong Chan
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations. Journal of chemical information and modeling 64 (6) (2024)
Eleanor Jing Yi Cheong, Sheng Yuan Chin, Zheng Wei Ng, Ting Jian Yap, Ervin Zhi Bin Cheong, Ziteng Wang, Eric Chun Yong Chan
Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement. Clinical pharmacokinetics (2023)
Jacqueline Wen Hui Leow, Xiao Jun Ang, Eric Chun Yong Chan
Development and verification of a physiologically based pharmacokinetic model of dronedarone and its active metabolite N-desbutyldronedarone: Application to prospective simulation of complex drug-drug interaction with rivaroxaban. British journal of clinical pharmacology (2023)
Lukasz Wojciech, Chin Wen Png, Eileen Yiling Koh, Yan Qin Dorinda Kioh, Lei Deng, Ziteng Wang, Liang-Zhe Wu, Maryam Hamidinia, Desmond Wh Tung, Wei Zhang, Sven Pettersson, Eric Chun Yong Chan, Yongliang Zhang, Kevin Shyong-Wei Tan, Nicholas R J Gascoigne
A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells. The EMBO journal (2023)
Ziteng Wang, Eric Chun Yong Chan
Role of Cytochrome P450 2C8 in Drug-Drug Interaction between Amiodarone and Nirmatrelvir/Ritonavir Via Physiologically-Based Pharmacokinetic Modeling. Clinical pharmacology and therapeutics (2023)
Jacqueline Wen Hui Leow, Xiao Jun Ang, Eric Chun Yong Chan
Development and verification of a physiologically-based pharmacokinetic model of dronedarone and its active metabolite N-desbutyldronedarone: application to prospective simulation of complex drug-drug interaction with rivaroxaban. British journal of clinical pharmacology (2023)
Ziteng Wang, Eric Chun Yong Chan
Inhibition of Cytochrome P450 2J2-Mediated Metabolism of Rivaroxaban and Arachidonic Acid by Ibrutinib and Osimertinib. Drug metabolism and disposition: the biological fate of chemicals 50 (10) (2022)
Lloyd Wei Tat Tang, Royden Yu Ren Lim, Gopalakrishnan Venkatesan, Eric Chun Yong Chan
Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells. Toxicology research 11 (2) (2022)
Keane Zhi Hao Lee, Ziteng Wang, Ching Yee Fong, Evelyn Mei Ling Goh, Hooi Moy Yan, Eric Chun Yong Chan
Identification of Optimal Urinary Biomarkers of Synthetic Cannabinoids BZO-HEXOXIZID, BZO-POXIZID, 5F-BZO-POXIZID, and BZO-CHMOXIZID for Illicit Abuse Monitoring. Clinical chemistry 68 (11) (2022)
Xin Qin Soh, Doreen Su Yin Tan, Eric Chun Yong Chan
Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore. Cardiovascular drugs and therapy (2022)
Le Duc Huy Ta, James Chun Yip Chan, Gaik Chin Yap, Chiung-Hui Huang, Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Noor Hidayatul Aini Suaini, Lynette Pei-Chi Shek, Neerja Karnani, Anne Eng Neo Goh, Hugo P S Van Bever, Oon Hoe Teoh, Yiong Huak Chan, Christophe Lay, Jan Knol, Fabian Yap, Kok Hian Tan, Yap-Seng Chong, Mary Foong-Fong Chong, Shiao Yng Chan, Johan Gunnar Eriksson, Keith M Godfrey, Eric Chun Yong Chan, Bee-Wah Lee
Prenatal diet, plasma micronutrients/metabolome and inflammatory status influence the development of atopic eczema in early childhood. Allergy (2022)
Lloyd Wei Tat Tang, Tino Woon Huai Cheong, Eric Chun Yong Chan
Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug-drug interactions with rivaroxaban. Biopharmaceutics & drug disposition 43 (2) (2022)
Ziteng Wang, Eric Chun Yong Chan
Physiologically-Based Pharmacokinetic Modeling-Guided Dose Management of Oral Anticoagulants when Initiating Nirmatrelvir/Ritonavir (Paxlovid) for COVID-19 Treatment. Clinical pharmacology and therapeutics 112 (4) (2022)
Yuxiang Gu, Haoran Chen, Xing Li, Dan Li, Yue Sun, Lin Yang, Ying Ma, Eric Chun Yong Chan
Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota-SCFA-hormone/inflammation pathway in mice. Journal of the science of food and agriculture (2022)
Chi Hon Sia, Ziteng Wang, Evelyn Mei Ling Goh, Yen Li Tan, Ching Yee Fong, Hooi Yan Moy, Eric Chun Yong Chan
Urinary Metabolite Biomarkers for the Detection of Synthetic Cannabinoid ADB-BUTINACA Abuse. Clinical chemistry 67 (11) (2022)
Lloyd Wei Tat Tang, Jian Wei Teng, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Eric Chun Yong Chan
Mechanism-Based Inactivation of Cytochrome P450 3A4 and 3A5 by the Fibroblast Growth Factor Receptor Inhibitor Erdafitinib. Chemical research in toxicology 34 (7) (2021)
Ziteng Wang, Eleanor Jing Yi Cheong, Pipin Kojodjojo, Eric Chun Yong Chan
Model-Based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population. Cardiovascular drugs and therapy (2021)
Eleanor Jing Yi Cheong, Daniel Zhi Wei Ng, Sheng Yuan Chin, Ziteng Wang, Eric Chun Yong Chan
Application of a PBPK Model of Rivaroxaban to Prospective Simulations of Drug-Drug-Disease Interactions with Protein Kinase Inhibitors in CA-VTE. British journal of clinical pharmacology (2021)
Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan, Eric Chun Yong Chan
Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone. Molecular pharmacology 99 (4) (2021)
Ziteng Wang, Ching Yee Fong, Evelyn Mei Ling Goh, Hooi Moy Yan, Eric Chun Yong Chan
Transesterification of Indazole-3-Carboxamide Synthetic Cannabinoids: Identification of Metabolite Biomarker for Diagnosing Co-Abuse of 5F-MDMB-PINACA and Alcohol. Journal of analytical toxicology (2021)
Wen Lie, Eleanor Jing Yi Cheong, Evelyn Mei Ling Goh, Hooi Yan Moy, Annelies Cannaert, Christophe P Stove, Eric Chun Yong Chan
Diagnosing intake and rationalizing toxicities associated with 5F-MDMB-PINACA and 4F-MDMB-BINACA abuse. Archives of toxicology 95 (2) (2020)
Sze Han Lee, Ratha Mahendran, Sin Mun Tham, Thomas Paulraj Thamboo, Billy Jianhao Chionh, Yi Xin Lim, Woon Chau Tsang, Qing Hui Wu, Jun Yang Chia, Melissa Hui Wen Tay, Benjamin Yen Seow Goh, Kelven Weijing Chen, Jeane Zepeda Mallari, Revathi Periaswami, Lata Raman, Shoa Nian Choo, Dorinda Yan Qin Kioh, Edmund Chiong, Kesavan Esuvaranathan, Eric Chun Yong Chan
Tryptophan-kynurenine ratio as a biomarker of bladder cancer. BJU international 127 (4) (2020)
Sze Han Lee, Ratha Mahendran, Sin Mun Tham, Thomas Paulraj Thamboo, Dorinda Yan Qin Kioh, Lloyd Wei Tat Tang, Edmund Chiong, Kesavan Esuvaranathan, Eric Chun Yong Chan
Combination Bacillus Calmette-Guérin and indoleamine 2,3-dioxygenase 1 inhibitor therapy of murine orthotopic bladder cancer. BJU international 126 (5) (2020)
Eleanor Jing Yi Cheong, Pramod C Nair, Rebecca Wan Yi Neo, Ho Thanh Tu, Fu Lin, Edmund Chiong, Kesavan Esuvaranathan, Hao Fan, Russell Z Szmulewitz, Cody J Peer, William Douglas Figg, Christina Li Lin Chai, John O Miners, Eric Chun Yong Chan
Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen. The Journal of pharmacology and experimental therapeutics 374 (3) (2020)
Eleanor Jing Yi Cheong, Denise Wun Xi Teo, Denise Xin Yi Chua, Eric Chun Yong Chan
Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban. Drug metabolism and disposition: the biological fate of chemicals 47 (11) (2019)
James Chun Yip Chan, Alex Cheow Khoon Soh, Dorinda Yan Qin Kioh, Jianguo Li, Chandra Verma, Siew Kwan Koh, Roger Wilmer Beuerman, Lei Zhou, Eric Chun Yong Chan
Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity. Molecular & cellular proteomics : MCP 17 (10) (2018)
Rou Hui Ho, James Chun Yip Chan, Hao Fan, Dorinda Yan Qin Kioh, Bee Wah Lee, Eric Chun Yong Chan
In Silico and in Vitro Interactions between Short Chain Fatty Acids and Human Histone Deacetylases. Biochemistry 56 (36) (2017)
James Chun Yip Chan, Pei Shi Ong, Peirong Lim, Preben Xiang Long Teng, Eric Chun Yong Chan
Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells. Cancer chemotherapy and pharmacology 79 (1) (2016)
Lian Yee Yip, Eric Chun Yong Chan
Investigation of Host-Gut Microbiota Modulation of Therapeutic Outcome. Drug metabolism and disposition: the biological fate of chemicals 43 (10) (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

Eric Chun Yong Chan