Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway.
Xuenan LiuZheng LiHao LiuYuan ZhuDandan XiaSiyi WangRanli GuWeiliang WuPing ZhangYunsong LiuYongsheng ZhouPublished in: Stem cell research & therapy (2019)
Collectively, our study suggested that low concentration FFA could be used in bone tissue engineering or osteoporosis by promoting osteogenic differentiation of human MSCs.
Keyphrases
- bone loss
- signaling pathway
- mesenchymal stem cells
- tissue engineering
- pi k akt
- umbilical cord
- bone mineral density
- endothelial cells
- induced apoptosis
- epithelial mesenchymal transition
- postmenopausal women
- lps induced
- induced pluripotent stem cells
- inflammatory response
- cell proliferation
- soft tissue
- pluripotent stem cells
- toll like receptor
- bone regeneration