Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior.
Sophie LeclercqFiroz M MianAndrew M StaniszLaure B BindelsEmmanuel CambierHila Ben-AmramOmry KorenPaul ForsytheJohn BienenstockPublished in: Nature communications (2017)
There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown that administration of high doses of antibiotics has long-term effects on brain neurochemistry and behaviour. Here we investigate whether low-dose penicillin in late pregnancy and early postnatal life induces long-term effects in the offspring of mice. We find that penicillin has lasting effects in both sexes on gut microbiota, increases cytokine expression in frontal cortex, modifies blood-brain barrier integrity and alters behaviour. The antibiotic-treated mice exhibit impaired anxiety-like and social behaviours, and display aggression. Concurrent supplementation with Lactobacillus rhamnosus JB-1 prevents some of these alterations. These results warrant further studies on the potential role of early-life antibiotic use in the development of neuropsychiatric disorders, and the possible attenuation of these by beneficial bacteria.
Keyphrases
- early life
- low dose
- blood brain barrier
- functional connectivity
- resting state
- cerebral ischemia
- healthcare
- case control
- high dose
- mental health
- public health
- white matter
- poor prognosis
- high fat diet induced
- young adults
- working memory
- squamous cell carcinoma
- preterm infants
- brain injury
- depressive symptoms
- subarachnoid hemorrhage
- high fat diet
- locally advanced
- social media
- radiation therapy