Mitochondrial dysfunction: The pathological link between psoriasis and insulin resistance?
Alejandra Villarreal-MartinezLaura Elia Martinez-de-VillarrealMinerva Gomez-FloresSonia Chavez-AlvarezRicardo Cerda-FloresJorge Ocampo CandianiConsuelo Ruiz-HerreraMarcelo R Rodriguez-RiveraJesús Zacarías Villarreal-PerezJosé Gerardo Gonzalez-GonzalezGeovana Calvo-AnguianoPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
Psoriasis patients with and without IR have a different acylcarnitine profile reflecting impaired ß-oxidation. A distinctive profile of acylcarnitines suggests an involvement of mitochondrial function associated with an increase in stearoyl CoA desaturase (SCD) activity in psoriatic patients with and without IR.