Minor temperature shifts do not affect chromosomal ploidy but cause transcriptomic changes in Leishmania braziliensis promastigotes in vitro.

Nathalia BallesterosNubia M VásquezLuz H PatiñoLissa Cruz-SaavedraJuan David Ramírez

Published in: Memorias do Instituto Oswaldo Cruz (2020)

This study provides evidence that L. braziliensis promastigotes exhibit a decrease in cell density, and noticeable changes in the transcriptomic profiles. However, there were not perceptible changes at chromosome CNVs and only ~3% of the genes changed their copies in each treatment.

Keyphrases

single cell
rna seq
copy number
stem cells
gene expression
combination therapy