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Minor temperature shifts do not affect chromosomal ploidy but cause transcriptomic changes in Leishmania braziliensis promastigotes in vitro.

Nathalia BallesterosNubia M VásquezLuz H PatiñoLissa Cruz-SaavedraJuan David Ramírez
Published in: Memorias do Instituto Oswaldo Cruz (2020)
This study provides evidence that L. braziliensis promastigotes exhibit a decrease in cell density, and noticeable changes in the transcriptomic profiles. However, there were not perceptible changes at chromosome CNVs and only ~3% of the genes changed their copies in each treatment.
Keyphrases
  • single cell
  • rna seq
  • copy number
  • stem cells
  • gene expression
  • combination therapy