Sensitive MRD detection from lymphatic fluid after surgery in HPV-associated oropharyngeal cancer.
Noah J EarlandNicholas P SemenkovichRicardo J RamirezSophie P GerndtPeter K HarrisZhuosheng GuAndrew I HearnMatthew J InkmanJeffrey J SzymanskiDamion WhitfieldBenjamin M WahleZhongping XuKevin ChenIrfan AlahiGabris NiAndrew ChenWendy WincklerJin ZhangAadel A ChaudhuriJose P ZevallosPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Variant and cf-HPV quantification, performed in 24-hour postoperative lymph samples, reflect single- and multi-feature high-risk pathological criteria. Incorporating lymphatic MRD and clinicopathological feature analysis can stratify PFS early after surgery in patients with HPV (+) head and neck cancer.