Plant-Derived Natural Compounds as an Emerging Antiviral in Combating COVID-19.
Mansi SinghShih-Hsiu LoRajni DubeySudhashekhar KumarKundan Kumar ChaubeySanjay KumarPublished in: Indian journal of microbiology (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human virus that burst at Wuhan in China and spread quickly over the world, leading to millions of deaths globally. The journey of this deadly virus to different mutant strains is still ongoing. The plethora of drugs and vaccines have been tested to cope up this pandemic. The herbal plants and different spices have received great attention during pandemic, because of their anti-inflammatory, and immunomodulatory properties in treating viruses and their symptoms. Also, it has been shown that nano-formulation of phytochemicals has potential therapeutic effect against COVID-19. Furthermore, the plant derived compound nano-formulation specifically increases its antiviral property by enhancing its bioavailability, solubility, and target-specific delivery system. This review highlights the potentiality of herbal plants and their phytochemical against SARS-CoV-2 utilizing different mechanisms such as blocking the ACE-2 receptors, inhibiting the main proteases, binding spike proteins and reducing the cytokine storms.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- anti inflammatory
- drug delivery
- endothelial cells
- escherichia coli
- signaling pathway
- working memory
- angiotensin ii
- high frequency
- induced pluripotent stem cells
- angiotensin converting enzyme
- pluripotent stem cells
- sleep quality
- disease virus
- depressive symptoms
- physical activity
- wild type
- dna binding