Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway.
Yonglong PanMengzhen HanXiaochao ZhangYi HeChaoyi YuanYixiao XiongXinxin LiChenglong ZengKan LuHe ZhuXun LuQiumeng LiuHuifang LiangZhibin LiaoZeyang DingZhanguo ZhangXiaoping ChenWanguang ZhangBixiang ZhangPublished in: Cellular oncology (Dordrecht) (2022)
Our study reveals a new mechanism by which DDR1 plays a liver cancer-promoting role. We also found that DDR1 expression serves as an independent prognostic marker, and that DDR1 and SLC1A5 expression levels are positively correlated in clinical samples. Our findings provide a new perspective for understanding HCC development and offers new targets for the treatment and management of HCC.