Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration.

Tomohiko SanoKoji AkedaJunichi YamadaNorihiko TakegamiTakao SudoAkihiro Sudo

Published in: BMC musculoskeletal disorders (2019)

The present study showed that the RANK/RANKL/OPG system may be involved in the progression of IVD degeneration. This study also suggested the potential use of anti-RANKL monoclonal antibody and OPG as therapeutic agents to suppress the progression of IVD degeneration.

Keyphrases

monoclonal antibody
endothelial cells
poor prognosis
nuclear factor
climate change
human health
binding protein