Lysosomal Polygenic Burden Drives Cognitive Decline in Parkinson's Disease with Low Alzheimer Risk.

Jon-Anders TunoldManuela M X TanMathias ToftOwen A RossWilma D J van de BergLasse Pihlstrom

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

Our study supports complex interplay between genetics and neuropathology in Parkinson's disease-related cognitive impairment, emphasizing the role of lysosomal polygenic burden. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

cognitive decline
mild cognitive impairment
cognitive impairment
risk factors
systematic review
randomized controlled trial