Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.

Hao Niu Edmond Atallah Ismael Alvarez-Alvarez Inmaculada Medina-Caliz Guruprasad Padur Aithal Cigdem Arikan Raúl Jesús Andrade María Isabel Lucena

Published in: Drug safety (2022)

This systematic review identified DILI in the paediatric population who have received specific treatment. These interventions appear to be mainly extrapolated from low-quality evidence from the adult population. Thus, there is a need for high-quality studies to test the efficacy of known and novel therapies to treat DILI specifically addressed to the paediatric population. PROSPERO registration number CRD42021214702.

Keyphrases

drug induced
liver injury
systematic review
intensive care unit
emergency department
meta analyses
randomized controlled trial
adverse drug
quality improvement
smoking cessation