Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.

Alina SchidlitzkiMilos StanojlovicCéline FournierChristopher KäuferMalte FejaBirthe GerickeMarco GarzottiRichard W D WelfordMichel Alexander SteinerElodie AngotFranziska Richter

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

Venglustat treatment in two mouse models of α-synuclein overexpression showed that glucosylceramide synthase inhibition had differential detrimental or beneficial effects on behavior and neuropathology possibly related to brain region-specific effects. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

mouse model
white matter
transcription factor
multiple sclerosis
systematic review
randomized controlled trial
metabolic syndrome
combination therapy
high fat diet induced
type diabetes
adipose tissue
skeletal muscle
subarachnoid hemorrhage
smoking cessation