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Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcohol Use Disorder.

Samantha J FedeMallory A KisnerThushini ManuweeraMike KerichReza Momenan
Published in: Alcohol and alcoholism (Oxford, Oxfordshire) (2022)
These findings suggest an increased concordance of networks underlying emotionality and compulsions toward drinking while also a reduction in control network connectivity, consistent with the addiction neurocircuitry model. Further, they suggest a compounding effect of continued heavy drinking on these vulnerabilities in neurocircuitry. More longitudinal research is necessary to understand the trajectories of individuals with AUD not adequately represented in this study, as well as whether this can inform effective harm reduction strategies.
Keyphrases
  • functional connectivity
  • resting state
  • alcohol use disorder
  • cross sectional
  • alcohol consumption
  • depressive symptoms
  • climate change
  • quality control
  • multiple sclerosis
  • white matter