Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis.

Sarah F AckleyScott C ZimmermanWilla D BrenowitzEric J Tchetgen TchetgenAudra L GoldJennifer J ManlyElizabeth Rose MayedaTeresa J FilshteinMelinda C PowerFanny M ElahiAdam M BrickmanMedellena Maria Glymour

Published in: BMJ (Clinical research ed.) (2021)

Pooled evidence from available trials reporting both reduction in amyloid levels and change in cognition suggests that amyloid reduction strategies do not substantially improve cognition.

Keyphrases

systematic review
mild cognitive impairment
white matter
meta analyses
randomized controlled trial
adverse drug