Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action.
Wei WangXinjie WangMehrdad RajaeiJi Youn YounAtif ZafarHemantkumar DeokarJohn K BuolamwiniJianhua YangJennifer H FosterJia ZhouRuiwen ZhangPublished in: Cancers (2020)
MDM2 inhibition by SP141 results in the inhibition of neuroblastoma growth and metastasis, regardless of the p53 status of the cells and tumors. These findings provide proof-of-concept that SP141 represents a novel treatment option for both p53 wild-type and p53 null neuroblastoma.