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Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action.

Wei WangXinjie WangMehrdad RajaeiJi Youn YounAtif ZafarHemantkumar DeokarJohn K BuolamwiniJianhua YangJennifer H FosterJia ZhouRuiwen Zhang
Published in: Cancers (2020)
MDM2 inhibition by SP141 results in the inhibition of neuroblastoma growth and metastasis, regardless of the p53 status of the cells and tumors. These findings provide proof-of-concept that SP141 represents a novel treatment option for both p53 wild-type and p53 null neuroblastoma.
Keyphrases
  • wild type
  • induced apoptosis
  • cancer therapy
  • stem cells
  • signaling pathway
  • mesenchymal stem cells
  • cell death