Placebo effect on progression and regression in NASH: Evidence from a meta-analysis.
Cheng Han NgJieling XiaoWen Hui LimYip Han ChinJie Ning YongDarren Jun Hao TanPhoebe TayNicholas SynRoger FooMark ChanNicholas ChewEunice Xx TanDaniel Q HuangYock Young DanNobuharu TamakiMohammad Shadab SiddiquiArun J SanyalStephen CaldwellMazen NoureddinMark Dhinesh MuthiahPublished in: Hepatology (Baltimore, Md.) (2022)
Despite the absence of any pharmacological interventions, a significant proportion of patients in the placebo arm demonstrated improvements in liver histology, highlighting the possibility that NASH is a disease that can not only progress but regress spontaneously over time. Additionally, histologic response in placebo-treated patients is helpful in future design of phase 2B and phase 3 trials.