The effect of cilostazol on the platelet-derived growth factor-beta/beta isoform reduction on venous hyperplasia in an experimental balloon-induced injury model.

Hugo Laparra-EscarenoAlette Ortega-GómezAlejandro Zentella-DehesaJoaquin Manzo-MerinoCarlos Acxel Vergara-AscencioMaria Del Carmen Antuñano-BlancoJose Roberto Lopez-SantacruzEduardo Esteban Montalvo-JaveJavier E Anaya-AyalaRodrigo Lozano-CoronaCarlos A Hinojosa

Published in: Vascular (2023)

Cilostazol induced a significant reduction of IH caused by barotrauma in the venous endothelium, which correlates with decrease in the PDGF-BB in serum. This could be attributed to the pharmacologic effect on PDGFR expression.

Keyphrases

growth factor
high glucose
diabetic rats
poor prognosis
nitric oxide
drug induced
endothelial cells
long non coding rna
smooth muscle