LncRNA SLNCR1 facilitates angiogenesis and tumor growth in melanoma via DNMT1-mediated epigenetically silencing SPRY2.

Ke LiLijun WuJingting Jiang

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2024)

SLNCR1 is an oncogene that interacts with DNMT1 to mediate SPRY2 methylation, thereby suppressing SPRY2 expression and promoting the angiogenesis and tumor growth in melanoma. SLNCR1 may serve as a potential target for melanoma treatment.

Keyphrases

dna methylation
endothelial cells
skin cancer
vascular endothelial growth factor
poor prognosis
long noncoding rna
binding protein
basal cell carcinoma
long non coding rna
signaling pathway
replacement therapy