Nucleoporin 107 is a prognostic biomarker in hepatocellular carcinoma associated with immune infiltration.
Ju-Sen NongXin ZhouJun-Qi LiuJian-Zhu LuoJia-Mi HuangHai-Xiang XieKe-Jian YangJing WangXin-Ping YeTao PengPublished in: Cancer medicine (2023)
NUP107 was highly expressed in 26 human cancers including HCC, and was associated with advanced HCC staging and worse prognosis. NUP107 showed satisfactory ability to predict the prognosis of HCC patients (AUC >0.8). Results of gene set enrichment analysis (GSEA) further showed that NUP107 was mainly associated with cell cycle-related pathways such as the cell cycle, DNA replication, G2M checkpoint, E2F target, and mitotic spindle. In addition, NUP107 was also associated with immune infiltration in HCC and showed significant positive correlation with immune checkpoints (PD-L1 and TIM-3).
Keyphrases
- cell cycle
- cell proliferation
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- lymph node
- peritoneal dialysis
- prognostic factors
- genome wide
- copy number
- pet ct
- young adults
- dna damage
- patient reported outcomes
- transcription factor
- pluripotent stem cells
- data analysis
- patient reported