In vitro evaluation of the anti-apoptotic drug Z-VAD-FMK on human ovarian granulosa cell lines for further use in ovarian tissue transplantation.
Maïté FransoletLaurie HenrySoraya LabiedAgnès NoëlMichelle NisolleCarine MunautPublished in: Journal of assisted reproduction and genetics (2015)
The death of granulosa cell lines was not induced in our ischemic model. Therefore, a protective effect of Z-VAD-FMK in vitro for further use in ovarian tissue transplantation could not be directly confirmed. It will be of interest to potentially use Z-VAD-FMK in vivo in xenograft models.
Keyphrases
- endothelial cells
- polycystic ovary syndrome
- cell death
- high glucose
- drug induced
- cell therapy
- diabetic rats
- emergency department
- stem cells
- ischemia reperfusion injury
- bone marrow
- pluripotent stem cells
- metabolic syndrome
- insulin resistance
- mesenchymal stem cells
- anti inflammatory
- cerebral ischemia
- blood brain barrier