4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.

Ting LiJia-Wen LiYing-Hui QinRiu LiuXiao-Na XuXiao LiLi-Min LiBin FengLi YangChun-Sheng Yang

Published in: Annals of clinical and translational neurology (2024)

4-OI could effectively inhibit NLRP3 signaling, leading to the inhibition of proinflammatory cytokine production in patients with NMOSD-derived PBMCs and in a human macrophage model. Thus, 4-OI and itaconate could have important therapeutic value for the treatment of NMOSD in the future.

Keyphrases

endothelial cells
oxidative stress
nlrp inflammasome
induced pluripotent stem cells
current status
pluripotent stem cells