Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population-based study in Sweden, Finland, and Denmark.

Mia Giertz Henri AarnivalaSascha Wilk MichelsenCaroline BjörklundAnnika EnglundMarika GrönroosLisa Lyngsie HjalgrimPasi HuttunenTuukka NiinimäkiEva PennoTuuli PöyhönenPäivi RaittinenSusanna RantaJohan E SvahnLisa TörnuddRiitta NiinimäkiArja Harila

Published in: Pediatric blood & cancer (2024)

This study shows that sON is as common in pediatric HL as in pediatric ALL, with risk factors such as older age, female sex, high cumulative GC doses, and advanced HL. Future HL protocol development should aim to reduce the burden of ON by modifying GC treatment.

Keyphrases

hodgkin lymphoma
risk factors
randomized controlled trial
young adults
gas chromatography
newly diagnosed
high resolution
replacement therapy