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Bone marrow impairment during early [ 177 Lu]PSMA-617 radioligand therapy: Haematotoxicity or tumour progression?

Felix KindKerstin MichalskiElham Yousefzadeh-NowshahrPhilipp T MeyerMichael MixJuri Ruf
Published in: EJNMMI research (2022)
During early cycles of PSMA-RLT, qualitative and quantitative bone marrow impairment appears to be closely associated with osseous tumour burden as only patients with advanced bone involvement and non-response to therapy exhibited high-grade haematological adverse events, showing a significant decline of haematological parameters. This implies that in patients with advanced mCRPC, non-response to PSMA-RLT may be a major cause of bone marrow impairment during early treatment cycles. German Clinical Trial Register DRKS00013665. Registered 28 December 2017, retrospectively registered ( www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00013665 ).
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