High burden of ESBL and carbapenemase-producing gram-negative bacteria in bloodstream infection patients at a tertiary care hospital in Addis Ababa, Ethiopia.
Daniel BeshahAdey Feleke DestaGurja Belay WoldemichaelEsmael Besufikad BelachewSolomon Gizaw DereseTizazu Zenebe ZelelieZelalem DesalegnTesfaye Sisay TessemaSolomon GebreselasieTamrat AbebePublished in: PloS one (2023)
Gram-negative bacteria were the main pathogens responsible for drug-resistant bloodstream infections. A high percentage of extended-spectrum-beta-lactamase and carbapenemase-producer bacteria were found in this study. Neonates were more susceptible to extended-spectrum-beta-lactamase and AmpC-beta-lactamase-producer bacteria. Patients in general surgery, caesarean section delivery, and intensive care unit were more susceptible to carbapenemase-producer bacteria. The suction machines, intravenous lines, and drainage tubes play an important role in the transmission of carbapenemase and metallo-beta-lactamase-producing bacteria. The hospital management and other stakeholders should work on infection prevention protocol implementation. Moreover, special attention should be given to all types of Klebsiella pneumoniae and pan-drug resistance Acinetobacter spp transmission dynamics, drug resistance genes, and virulence factors.
Keyphrases
- klebsiella pneumoniae
- multidrug resistant
- drug resistant
- gram negative
- acinetobacter baumannii
- escherichia coli
- intensive care unit
- healthcare
- end stage renal disease
- ejection fraction
- staphylococcus aureus
- primary care
- prognostic factors
- newly diagnosed
- randomized controlled trial
- working memory
- ultrasound guided
- peritoneal dialysis
- biofilm formation
- chronic kidney disease
- high dose
- low dose
- gene expression
- preterm infants
- quality improvement
- candida albicans
- extracorporeal membrane oxygenation