Influence of E-cadherin deficiency on the dendrite morphology of Langerhans cells.

Britta DornCindy RuhlandStefanie KunzPhilipp R Esser Thilo Jakob

Published in: European journal of immunology (2024)

The expression of E-cadherin on Langerhans cells (LC) is required for adequate dendrite intercalation between epidermal keratinocytes. Upon disruption of epidermal homeostasis by tape stripping, E-cadherin competent LC extend dendrites reaching up to the epidermal surface, while E-cad deficient LC lack this ability.

Keyphrases

induced apoptosis
cell cycle arrest
simultaneous determination
wound healing
coronary artery disease
mass spectrometry
poor prognosis
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
liquid chromatography
high resolution
binding protein
replacement therapy