Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk.
Kristina M JordahlAmanda I PhippsTimothy W RandolphLesley F TinkerRami NassirLifang HouGarnet L AndersonKarl T KelseyEmily WhiteParveen BhattiPublished in: BMC medical genetics (2020)
Though larger studies are necessary, the methylation changes associated with rs401681 and rs2294008 at mQTL-associated CpG sites may be relevant for bladder carcinogenesis, and this study demonstrates how multi-omic data can be integrated to help understand the downstream effects of genetics variants.