Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk.

Kristina M JordahlAmanda I PhippsTimothy W RandolphLesley F TinkerRami NassirLifang HouGarnet L AndersonKarl T KelseyEmily WhiteParveen Bhatti

Published in: BMC medical genetics (2020)

Though larger studies are necessary, the methylation changes associated with rs401681 and rs2294008 at mQTL-associated CpG sites may be relevant for bladder carcinogenesis, and this study demonstrates how multi-omic data can be integrated to help understand the downstream effects of genetics variants.

Keyphrases

dna methylation
genome wide
copy number
gene expression
spinal cord injury
electronic health record
social support
machine learning
big data
data analysis
urinary tract