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Acute Dissociation and Ketamine's Antidepressant and Anti-Suicidal Ideation Effects in a Midazolam-Controlled Trial.

Sumra SajidHanga C GalfalvyJohn G KeilpAinsley K BurkeJ John MannMichael F Grunebaum
Published in: The international journal of neuropsychopharmacology (2024)
We did not find evidence that ketamine's acute, transient dissociative, or psychotomimetic effects are associated with its antidepressant or anti-suicidal ideation actions. The correlation of higher plasma norketamine with lower dissociative symptoms on Day 1 post-treatment suggests dissociation may be more an effect of the parent drug.
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