Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human.

Ya-Xin FanYuan-Cheng ChenYi LiJi-Cheng YuXing-Chen BianXin LiWan-Zhen LiBei-Ning GuoHai-Lan WuXiao-Fen LiuYu WangXiao-Yong XuJia-Li HuJing-Jing WangXiao-Jie WuGuo-Ying CaoJu-Fang WuChun-Jia XueJun FengYing-Yuan ZhangJing Zhang

Published in: Pharmaceutical research (2021)

The difference in component content in the two CMS formulas had a significant (P < 0.001) impact on the systemic exposure of colistin in human, thus, warranted essential considerations in clinical applications.

Keyphrases

escherichia coli
pseudomonas aeruginosa
acinetobacter baumannii
endothelial cells
klebsiella pneumoniae
multidrug resistant
drug resistant
gram negative
induced pluripotent stem cells
pluripotent stem cells
drug delivery
drug release
drug induced