[Proteins of insuline-like growth factor system in tumor and ascites in ovarian cancer: the relation with neoajuvant chemotherapy effectiveness].
A B VillertL A KolomietsI V KondakovaL V SpirinaN V YunusovaPublished in: Voprosy onkologii (2019)
The purpose of the study was to investigate insulin-like growth factors (IGFs) levels in primary tumors and ascites be- fore neoadjuvant chemotherapy (NACT) for searching markers -predictors, associated with its efficiency. The content of IGFs, IGFBPs and receptor IGF-IR is analyzed in primary tumor tis- sues and ascites of 47 patients with high grade ovarian serous adenocarcinomas. The results show a high concentration of IGFs and IGFBPs in ascites as compared with tumor samples. It is found the increase of IGF-II as well as the decrease of IGFBP-3 and tyrosine kinase receptor IGF-IR levels in I stage cancer patients in comparison to patients with advanced ovar- ian cancer. It is obtained the fact of dependence IGFs and IGFBPs levels on the volume of ascites. This factors as well as IGFs protein content are significant markers - predictors of NACT efficiency in group of patients with high grade serous adenocarcinomas.
Keyphrases
- high grade
- neoadjuvant chemotherapy
- cell free
- growth factor
- low grade
- tyrosine kinase
- binding protein
- locally advanced
- type diabetes
- randomized controlled trial
- squamous cell
- epidermal growth factor receptor
- systematic review
- squamous cell carcinoma
- papillary thyroid
- sentinel lymph node
- rectal cancer
- skeletal muscle
- metabolic syndrome
- lymph node metastasis