New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro.
Muluneh M FasheMerja R HäkkinenRami El-DairiMarkku PasanenRisto Olavi JuvonenPublished in: Rapid communications in mass spectrometry : RCM (2018)
7-GSH-DHP (CHO) has not been reported before, and thus it was considered as a novel metabolite of PAs. This may clarify the mechanisms involved in PA detoxification and widely observed but less understood species differences in response to PA exposure.