Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration.
Ulf LindströmDaniela Di GiuseppeBénédicte DelcoigneBente GlintborgBurkhard MöllerAdrian CiureaManuel Pombo-SuarezCarlos Sanchez-PiedraKari EklundHeikki RelasBjorn GudbjornssonThorvardur Jon LoveGareth T JonesCatalin CodreanuRuxandra IonescuLucie NekvindovaJakub ZávadaNuh AtasServet YolbasKaren Minde FagerliBrigitte MichelsenŽiga RotarMatija TomšičFlorenzo IannoneMaria Jose SantosPedro Avila-RibeiroLykke Midtbøll ØrnbjergMikkel ØstergaardLennart Th JacobssonJohan AsklingMichael J NissenPublished in: Annals of the rheumatic diseases (2021)
This large observational study suggests that, as used in clinical practice, csDMARD and TNFi comedication are associated with improved remission rates, and specifically, comedication with methotrexate increases remission rates for both adalimumab and infliximab.