Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study.
Anouk BokslagConstantijn FranssenLisa J AlmaIgor KovacevicFloortje van KesterenPim W TeunissenOtto KampWessel J GanzevoortPeter L HordijkChristianne J M de GrootWalter J PaulusPublished in: PloS one (2018)
History of preeclampsia predisposes in middle age to worse LV diastolic function, which could increase the likelihood of later HFpEF development. This predisposition derives not only from persistent cardiovascular risk but may also be caused by persistent endothelial dysfunction hindering adequate vascularization in the uterus during pregnancy and in the myocardium in middle age.
Keyphrases
- early onset
- left ventricular
- late onset
- hypertrophic cardiomyopathy
- blood pressure
- cardiac resynchronization therapy
- acute myocardial infarction
- heart failure
- aortic stenosis
- left atrial
- mitral valve
- ejection fraction
- cell therapy
- stem cells
- acute coronary syndrome
- bone marrow
- pregnant women
- tissue engineering
- transcatheter aortic valve replacement
- percutaneous coronary intervention