Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis.

Asma BoumazaLaetitia GaySoraya MezouarEloïne BestionAïssatou Bailo DialloMoise MichelBenoit DesnuesDidier RaoultBernard La ScolaPhilippe HalfonJoana VitteDaniel OliveJean-Louis Mege

Published in: The Journal of infectious diseases (2021)

SARS-CoV-2 drives monocytes and macrophages to induce host immunoparalysis for the benefit of COVID-19 progression.SARS-CoV-2 infection of macrophages induces a specific M2 transcriptional program. In Covid-19 patients, monocyte subsets were decreased associated with up-expression of the immunoregulatory molecule CD163 suggesting that SARS-CoV-2 drives immune system for the benefit of Covid-19 disease progression.

Keyphrases

respiratory syndrome coronavirus
sars cov
coronavirus disease
peripheral blood
dendritic cells
poor prognosis
gene expression
quality improvement
endothelial cells
binding protein
heat shock