HSP4 triggers epithelial-mesenchymal transition and promotes motility capacities of hepatocellular carcinoma cells via activating AKT.

Peng MaWei-Guo TangJin-Wu HuYing HaoLiang-Kun XiongMao-Ming WangHao LiuWen-Hui BoKai-Huan Yu

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

HSF4 is upregulated in HCC, resulting in greater proliferation, migration and invasion capacities. Moreover, high HSF4 expression is a promising predictive indicator of poor outcome after radical resection. HSF4 may promote aggressive tumour behaviour by enhancing EMT through activating AKT pathway in a HIF1α-dependent manner.

Keyphrases

signaling pathway
epithelial mesenchymal transition
heat shock
transforming growth factor
heat shock protein
heat stress
poor prognosis
oxidative stress
cell proliferation
endothelial cells
biofilm formation
binding protein
long non coding rna
escherichia coli
pseudomonas aeruginosa
candida albicans