Tigecycline Suppresses the Virulence Factors of Multidrug-Resistant Acinetobacter baumannii Allowing Human Neutrophils to Act.
Yoshinori SatoNami HatayamaTsuneyuki UbagaiShigeru Tansho-NagakawaYasuo OnoYusuke YoshinoPublished in: Infection and drug resistance (2022)
TGC significantly suppressed the expression of catalase and the capsule in MDRAB without adverse effects on neutrophil function, allowing human neutrophils to kill MDRAB. TGC is an effective antibiotic for treating MDRAB infections.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- pseudomonas aeruginosa
- drug resistant
- endothelial cells
- gram negative
- klebsiella pneumoniae
- escherichia coli
- induced pluripotent stem cells
- pluripotent stem cells
- cystic fibrosis
- emergency department
- antimicrobial resistance
- adverse drug
- drug induced
- electronic health record