Jin-Gui-Shen-Qi Wan ameliorates diabetic retinopathy by inhibiting apoptosis of retinal ganglion cells through the Akt/HIF-1α pathway.

Dan LiangYulin QiLu LiuZhaoxia ChenShiyun TangJianyuan TangNianzhi Chen

Published in: Chinese medicine (2023)

These results indicated that in the db/db DR mouse model, JGSQ can inhibit the expression of inflammatory cytokines and protect retinal ganglion cells from apoptosis, possibly by modulating the Akt/HIF-1α pathway.

Keyphrases

cell cycle arrest
signaling pathway
pi k akt
diabetic retinopathy
induced apoptosis
mouse model
cell death
endoplasmic reticulum stress
oxidative stress
cell proliferation
optical coherence tomography
poor prognosis
endothelial cells
long non coding rna