Clinical study of MAP2K1-mutated Langerhans cell histiocytosis in children.

Ying YangChanjuan WangDong WangLei CuiNa LiHongyun LianHonghao MaYunze ZhaoLiping ZhangWei LiuYizhuo WangWanshui WuRui ZhangZhigang LiTianyou Wang

Published in: Journal of cancer research and clinical oncology (2021)

The children with MAP2K1-mutated LCH have specific clinical features requiring clinical stratification and precise treatment. MAP2K1-mutated patients with lung involvement (especially with bony thorax involvement) had poor prognosis.

Keyphrases

poor prognosis
long non coding rna
young adults
high density
wild type
single cell
clinical trial
double blind
replacement therapy