Metabolic phenotyping of healthy and diseased human RPE cells.

Saira RizwanBeverly ToothmanBo LiAbbi J EngelRayne R LimJinyu LuJennifer R ChaoJianhai Du

Published in: bioRxiv : the preprint server for biology (2024)

Epithelial phenotype confers metabolic flexibility to the RPE for utilizing various nutrients. SFD RPE cells have reduced metabolic flexibility, relying on the oxidation of BCAAs. Our findings highlight the importance of nutrient availability and utilization in RPE differentiation and diseases.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway
heavy metals
nitric oxide
hydrogen peroxide
induced pluripotent stem cells
pluripotent stem cells