Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer.
Kim WongFederico AbascalLatasha LudwigHeike Aupperle-LellbachJulia GrassingerColin W WrightSimon J AllisonEmma PinderRoger M PhillipsLaura P RomeroArnon GalPatrick J RoadyIsabel PiresFranco GuscettiJohn S MundayMaria C PeleteiroCarlos A PintoTânia CarvalhoJoão CotaElizabeth C Du PlessisFernando Constantino-CasasStephanie PlogLars MoeSimone de BrotIngrid BemelmansRenée Laufer AmorimSmitha R GeorgyJustina PradaJorge Del PozoMarianne HeimannLouisiane de Carvalho NunesOuti SimolaPaolo PazziJohan SteylRodrigo UbukataPeter VajdovichSimon L PriestnallAlejandro Suárez-BonnetFranco RopertoFrancesca MillantaChiara PalmieriAna L OrtizClaudio S L BarrosAldo GavaMinna E SöderströmMarie O'DonnellRobert KlopfleischAndrea Manrique-RincónInigo MartincorenaIngrid FerreiraMark J ArendsGeoffrey A WoodDavid J AdamsLouise van der WeydenPublished in: Genome biology (2023)
Canine and feline urinary bladder UC represent relevant models of MIBC in humans, and cross-species analysis can identify evolutionarily conserved driver genes. We characterize mutational signatures in bovine UC associated with bracken fern and ptaquiloside exposure, a human-linked cancer exposure. Our work demonstrates the relevance of cross-species comparative analysis in understanding both human and animal UC.