LatY136F knock-in mouse model for human IgG4-related disease.

Kazunori YamadaMasahiko ZukaKiyoaki ItoKeishi MizuguchiYasushi KakuchiTamehito OnoeYasunori SuzukiMasakazu YamagishiShozo IzuiMarie MalissenBernard MalissenMitsuhiro Kawano

Published in: PloS one (2018)

LatY136F knock-in mice displayed increased production of Th2-type IgG1 (a homologue of human IgG4) and developed multiple organ tissue lesions reminiscent of those seen in patients with IgG4-RD. Moreover, the development of these tissue lesions was highly sensitive to corticosteroid treatment like in IgG4-RD. For these reasons we consider the LatY136F knock-in mouse strain to represent a promising model for human IgG4-RD.

Keyphrases

endothelial cells
mouse model
induced pluripotent stem cells
pluripotent stem cells
type diabetes
metabolic syndrome
mass spectrometry
insulin resistance
liquid chromatography