Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data.

Johannes Kaesmacher Thomas Raphael MeinelChristoph KurmannOsama O ZaidatAlicia C CastonguaySyed F ZaidiNils Mueller-KronastManon KappelhofDiederik W J DippelMarc SoudantSerge BracardMichael D Hill Mayank GoyalDaniel StrbianDaniel M HeifermanWilliam AshleyMohammad AnadaniAlejandro M SpiottaTomas Dobrocky Eike Immo I PiechowiakMarcel ArnoldMartina GoeldlinDavid SeiffgePascal J MosimannPasquale MordasiniJan GrallaUrs Fischer

Published in: Journal of neurointerventional surgery (2021)

The quality of evidence regarding peri-interventional administration of IA fibrinolytics in MT is low and limited to observational data. In highly selected patients, no increase in sICH was observed, but there is large uncertainty.

Keyphrases

electronic health record
end stage renal disease
ejection fraction
big data
cross sectional
patient reported outcomes
quality improvement