Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data.
Johannes KaesmacherThomas Raphael MeinelChristoph KurmannOsama O ZaidatAlicia C CastonguaySyed F ZaidiNils Mueller-KronastManon KappelhofDiederik W J DippelMarc SoudantSerge BracardMichael D HillMayank GoyalDaniel StrbianDaniel M HeifermanWilliam AshleyMohammad AnadaniAlejandro M SpiottaTomas DobrockyEike Immo I PiechowiakMarcel ArnoldMartina GoeldlinDavid SeiffgePascal J MosimannPasquale MordasiniJan GrallaUrs FischerPublished in: Journal of neurointerventional surgery (2021)
The quality of evidence regarding peri-interventional administration of IA fibrinolytics in MT is low and limited to observational data. In highly selected patients, no increase in sICH was observed, but there is large uncertainty.