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Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data.

Johannes KaesmacherThomas Raphael MeinelChristoph KurmannOsama O ZaidatAlicia C CastonguaySyed F ZaidiNils Mueller-KronastManon KappelhofDiederik W J DippelMarc SoudantSerge BracardMichael D HillMayank GoyalDaniel StrbianDaniel M HeifermanWilliam AshleyMohammad AnadaniAlejandro M SpiottaTomas DobrockyEike Immo I PiechowiakMarcel ArnoldMartina GoeldlinDavid SeiffgePascal J MosimannPasquale MordasiniJan GrallaUrs Fischer
Published in: Journal of neurointerventional surgery (2021)
The quality of evidence regarding peri-interventional administration of IA fibrinolytics in MT is low and limited to observational data. In highly selected patients, no increase in sICH was observed, but there is large uncertainty.
Keyphrases
  • electronic health record
  • end stage renal disease
  • ejection fraction
  • big data
  • cross sectional
  • patient reported outcomes
  • quality improvement