Integrated molecular analysis reveals hypermethylation and overexpression of HOX genes to be poor prognosticators in IDH mutant glioma.

Yasin MamatjanMathew VoisinFarshad NassiriFabio Y MoraesSevera BundaJonathan SoMira SalihMitsuaki ShirahataTakahiro OnoHiroaki ShimizuDaniel SchrimpfAndreas von DeimlingKenneth D AldapeGelareh Zadeh

Published in: Neuro-oncology (2023)

HOX gene methylation and expression provide important prognostic information in IDH-mutant gliomas that are not captured by current molecular diagnostics. A 7-HOX gene signature of outcome shows significant survival differences in both 1p/19q codeleted and non-codeleted IDH-mutant gliomas.

Keyphrases

wild type
genome wide
high grade
low grade
genome wide identification
copy number
dna methylation
poor prognosis
transcription factor
genome wide analysis
cell proliferation
free survival
social media