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A phase 1 trial of 4-(N-(S-penicillaminylacetyl)amino)-phenylarsonous acid (PENAO) in patients with advanced solid tumours.

Sunit SarkarBen TranLisa G HorvathMichael LamPeter SavasPeter S GrimisonJames R WhittleJames C KuoNicole SignalDavid EdmondsPhilip J HoggDanny RischinJayesh DesaiAnne Hamilton
Published in: Cancer chemotherapy and pharmacology (2021)
PENAO was administered by CIVI at dose levels up to 9 mg/m2/day with only one DLT noted. Pharmacokinetic studies invalidated the rationale for continuous dosing and led to discontinuation of the trial without defining a RP2D. Future clinical development of PENAO will use intermittent dosing schedule, alone and in combination with rapamycin.
Keyphrases
  • clinical trial
  • study protocol
  • phase iii
  • current status
  • phase ii
  • high intensity
  • case control
  • randomized controlled trial
  • open label
  • double blind